
Shahamirian was born in Nor Jugha, the notable Armenian community established at the beginning of the seventeenth century as a suburb of Isfahan, the Persian capital. He migrated to Madras and made an important fortune in commercial activities. Influenced by the progressive ideas of a group of fellow Armenians who were engaged in a drive to liberate their homeland from foreign yoke, Shahamirian established the first Armenian printing house of Madras in 1771 on behalf of his young son Hakob (1745-1774). A year later, he published a book co-authored by Hakob and his teacher Movses Baghramian, one of the theoreticians of the group, entitled «Նոր տետրակ, որ կոչի Յորդորակ» (Nor tetrak, vor kochi Hordorak, namely, “New Fascicle Called Advice”).
Hakob Shahamirian, a talented young man who died at the age of 29 in Malacca (Malaysia), seems to have authored much of the text of the most important book produced by the Madras group, «Որոգայթ փառաց» (Vorogayt parats, “Snare of Glory”), in 1773. The book was left unfinished, apparently, at his death, and meanwhile, his father published another pamphlet authored by Baghramian, «Նոր տետրակ, որ կոչի Նշաւակ» (Nor tetrak, vor kochi Nshavak, namely, “New Fascicle Called Target”) in 1783. This was the bylaws of self-government for the Armenians of Madras.

Shahamir Shahamirian tried to get in touch with the Georgian king Heraclius II (1744-1801) in order to achieve the liberation of the Southern Caucasus from Persian and Turkish domination through an Armeno-Georgian alliance. However, understanding that such an alliance was not enough, he later established contacts with the Russian courts, as well with other activists of Armenian liberation, such as Prince Hovsep Arghutian, Hovhannes Lazarian, and others. He passed away in 1797.